Researchers Discovered New Immune System Biomarkers

According to the latest news researchers have discovered new immune system biomarkers which enables the scientists to predict how soon the HIV virus will return if a patient stops taking his medications and therapies to treat their condition. This latest discovery has been researched at the University of New South Wales, and the University of Oxford.

This research has provided numerous benefits and scopes in the sector of HIV Research and Development. It has enabled the scientists to understand why does the HIV virus remain active in some patients whereas dormant or even completely undetectable in others.

Although the antiretroviral treatment for HIV infection, which is by far the best available treatment present till date to treat this deadly virus, helps to stops the virus from replicating itself and making further damage to the body organs but it does not actually cure the disease. Determining how to kill the reservoirs of HIV virus still remains the most priority target of scientists and researchers. Fortunately, this latest research has provided a lot of info and help in determining how to kill these reservoirs which is the major achievement of this research.

The research was basically led by Professor John Frater, a researcher at the Oxford University. The team emphasized on analyzing the data gathered from a random study of patients of HIV infection who were still at theĀ primary stage of the infection. In order to gather analyzable data they compared the CD4+ cells in 154 patients in Brazil, Australia and Europe who had their antiretroviral treatment interrupted after 12-48 weeks.

The researchers shortlisted 18 immune system biomarks and by analyzing this data they discovered that 3 of them – Tim-3, Lag-3 and PD-1 were statistically very important predictors of determining when the virus would rebound or reform. The researchers found out that high level of these particular biomarks that were attached to the exhausted CD4+ cells before the patients started their ART treatment were associated with an early reformation of the virus in the body after interruption in the treatment. The findings of this research were published in the journal Nature Communications

 

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